Center for Innovation in Brain Science
News & Announcements
Women make up nearly two-thirds of the more than 5 million Americans with Alzheimer’s disease and shoulder the majority of the caregiving for those with dementia.
For estrogen to function as master regulator of the bioenergetic system in the female brain, estrogen must be integrating nuclear and mitochondrial genomic responses. Further, from a systems level perspective, it would be necessary for estrogen to also regulate cytoplasmic signaling mechanisms for real time feedback on the functional outcomes of nuclear and mitochondrial gene transcription. The fundamental issues to be investigated are the mechanisms whereby estrogen integrates bioenergetic responses across two genomic compartments while simultaneously monitoring energetic demand and performance in real time. Estrogenic control of the bioenergetic system of the brain and the dismantling thereof has basic, translational and clinical significance.
Disruptive Women seeks to highlight women from a broad cross-section of disciplines, all of whom profoundly impact health and health care. This year we are doing something different. Given the enormity of the issues we are facing globally, when it comes to Alzheimer’s Disease and related dementias, we are focusing this year’s class of extraordinary women on those who are committed to ridding the world of this scourge.