Women make up nearly two-thirds of the more than 5 million Americans with Alzheimer’s disease and shoulder the majority of the caregiving for those with dementia.
For estrogen to function as master regulator of the bioenergetic system in the female brain, estrogen must be integrating nuclear and mitochondrial genomic responses. Further, from a systems level perspective, it would be necessary for estrogen to also regulate cytoplasmic signaling mechanisms for real time feedback on the functional outcomes of nuclear and mitochondrial gene transcription. The fundamental issues to be investigated are the mechanisms whereby estrogen integrates bioenergetic responses across two genomic compartments while simultaneously monitoring energetic demand and performance in real time. Estrogenic control of the bioenergetic system of the brain and the dismantling thereof has basic, translational and clinical significance.
Disruptive Women seeks to highlight women from a broad cross-section of disciplines, all of whom profoundly impact health and health care. This year we are doing something different. Given the enormity of the issues we are facing globally, when it comes to Alzheimer’s Disease and related dementias, we are focusing this year’s class of extraordinary women on those who are committed to ridding the world of this scourge.
She says companies don’t find Alzheimer’s, which disproportionately affects women, “sexy”. Each October, a parade of major American companies across the business spectrum unite to promote women’s health for Breast Cancer Awareness Month. But there’s not nearly as much corporate activism when it comes to another disease with a massive gender gap: Alzheimer’s. And that needs to change if there’s any hope for finding a cure, argues journalist and activist Maria Shriver.
Fortune Brainstorm HEALTH will offer a dynamic mix of one-on-one interviews, panel discussions, interactive roundtables and far-ranging Q&As. Brainstorm HEALTH will bring the signature Fortune Brainstorm interactive format to generate new ideas and fresh thinking, while encouraging a hand-selected group of thought-leaders to work jointly on problem solving. Participants will tackle the big questions of how technology can reshape all aspects of health, including personal wellness, intervention, cost efficiency, and research. Fortune’s goal is to gather together those on the front lines of the industry, provide a forum for them to share their cutting-edge ideas on how businesses can lead in this field, and then disseminate these ideas in the magazine and beyond.
The Alzheimer’s tsunami is coming. More than 5 million Americans are currently living with the disease, and that number is expected to triple by 2050, placing a staggering burden on society. And nowhere does this burden weigh heavier than on the shoulders of women, who make up two-thirds of all Americans with Alzheimer’s, as well as the majority of unpaid caregivers for family and friends living with this disease. While a race for the cure is on, what can millions of Americans do today to prevent the onset of this debilitating disease? What does new research need to focus on? And what can be learned from women’s brains? Dr. Roberta Diaz Brinton, Director, Center for Innovation in Brain Science,University of Arizona Health Sciences Maria Shriver, Journalist; Founder, The Women’s Alzheimer’s Movement Moderator: Dr. David B. Agus, USC
A five-year National Institute on Aging program project grant will be led by Roberta Diaz Brinton, inaugural director of the Center for Innovation in Brain Science at the UA Health Sciences.
TUCSON, Ariz. – Why do more women than men get Alzheimer’s disease? In their quest to find the answer, neuroscientist Roberta Diaz Brinton, PhD, and her collegues in the Center for Innovation in Brain Science at the University of Arizona Health Sciences, have been awarded a $10.3 million five-year Program Project Grant (PPG) from the National Institute on Aging at the National Institutes of Health.
An estimated 120,000 people age 65 and older in Arizona have Alzheimer’s disease, according to the Alzheimer’s Association, and the number is expected to increase to 200,000 by 2025, a change of more than 66 percent. Women are disproportionately affected.
The University of Arizona has made brain research a focal point in its creation of a new Center for Innovation in Brain Science. The center draws from expertise in science, engineering and informatics, the science of information. The brain science center will be a collaborative effort of experts in a variety of disciplines from across the state.
Internationally renowned neuroscientist to lead efforts to accelerate the advancement of evidence-based clinical care of brain disorders caused by disease, genetics or trauma.